环境污染和人类生育能力:研究PM2.5暴露与辅助生殖技术结果之间的关系
Fei Li1, Xiaoyan Duan1, Mingming Li2
1Center for Reproductive Medicine, Clinical College, The First People'S Hospital of Shangqiu, Xinxiang Medical University, 292 Kaixuan South Road, Shangqiu, Henan, China.
BMC public health
|April 11, 2025
概括
暴露于细颗粒物 (PM2.5) 对辅助生殖技术 (ART) 的成功率产生负面影响,减少怀孕和活产率. 季节性PM2.5水平的变化显著影响ART的结果,冬季暴露显示出最低的成功率.
科学领域:
- 环境健康 环境健康
- 生殖医学 生殖医学
- 毒理学 毒理学 毒理学
背景情况:
- 空气动力学直径为2.5微米或更小的颗粒物 (PM2.5) 是广泛存在的环境污染物.
- 以前的研究表明,空气污染可能会影响人类健康,包括生殖结果.
- 季节性PM2.5变化对辅助生殖技术 (ART) 成功的具体影响需要进一步研究.
研究的目的:
- 调查PM2.5暴露季节性变化对ART结果的影响.
- 评估PM2.5度与卵细胞质量,胚胎发育,怀孕率和活产率之间的关系.
主要方法:
- 这是一项回顾性研究,分析了13476次ART手术 (2018-2022) 的数据.
- 根据季节性PM2.5暴露水平分类的患者.
- 一般化添加模型,线性回归和多变量逻辑回归用于分析关联.
主要成果:
- 在季节性PM2.5暴露组中观察到卵细胞和胚胎质量的显著差异.
- 暴露于PM2.5与怀孕和活产率有负相关性 (p < 0.001).
- 在PM2.5和流产率之间没有发现显著的关联;在春季,夏季和秋季发现的非线性效应与更高的活产率有关.
结论:
- 暴露于PM2.5会对ART成功产生不利影响,降低怀孕和活产率.
- 在PM2.5的季节性变化显著影响ART的结果.
- 需要制定策略来减轻环境污染对ART的不利影响.
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