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Updated: May 14, 2025

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由矩阵金属蛋白酶驱动的表皮质-介质酶过渡:对健康和疾病的影响
Ghazaleh Khalili-Tanha1, Evette S Radisky2, Derek C Radisky2
1Department of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Journal of translational medicine
|April 11, 2025
概括
矩阵金属蛋白酶 (MMPs) 驱动上皮层-介质酶过渡 (EMT),这是对发育至关重要的过程,但与纤维化和癌症有关. 针对MMP提供了对病态EMT的治疗潜力.
科学领域:
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 表皮介质转变 (EMT) 是一个基本的生物过程,涉及到发育和组织修复.
- 失调的EMT有助于疾病状况,如纤维化,炎症和癌症转移.
- 矩阵金属蛋白酶 (MMPs) 是细胞外矩阵的关键调节者,在EMT中发挥关键作用.
研究的目的:
- 提供MMP启动和维持EMT的分子机制的综合概述.
- 讨论MMPs在生理和病理条件中的作用,包括纤维化和癌症.
- 探索针对MMP和EMT的新兴治疗策略.
主要方法:
- 文献综述侧重于EMT中MMPs的分子机制.
- 对MMPs参与信号通路 (例如TGF-β,Wnt/β-catenin) 和细胞过程的分析.
- 探索针对MMP和EMT的治疗干预措施.
主要成果:
- MMPs拆解地下室膜,激活pro-EMT通路,并分裂粘附分子,驱动EMT.
- 异常的MMP调节促进了过度的ECM周转,助长了纤维化和癌症的进展.
- MMPs通过TGF-β,Wnt/β-catenin信号传递来增强EMT,破坏细胞结合,并增强缺氧诱导因子活性.
结论:
- 在生理和病理EMT中,MMP是核心的.
- 失调的MMP活性驱动纤维化中的组织重塑,并推动癌症的入侵和转移.
- 针对性地抑制MMP和EMT为疾病提供了有前途的治疗途径.
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