评估胎儿大脑在孕产妇甲状腺功能低下和甲状腺自身抗体阳性:一个前性病例对照研究
Raziye Torun1, Hakan Golbasi1, Ceren Saglam1
1Department of Perinatology, Izmir City Hospital, 35510 Izmir, Turkey.
Journal of clinical medicine
|April 12, 2025
概括
有或没有甲状腺抗体的孕产妇甲状腺功能低下症可能会微妙地影响胎儿的大脑发育,特别是在怀孕中期影响乳腺体和后侧心室 (PLV) 大小.
科学领域:
- 孕产妇和胎儿的医学
- 发育神经科学的发展神经科学.
- 内分泌学 在内分泌学.
背景情况:
- 孕产妇的甲状腺功能对于胎儿大脑发育至关重要.
- 孕产妇甲状腺功能低下和甲状腺自身免疫对胎儿大脑结构的影响尚不清楚.
- 这项研究探讨了这些影响在怀孕中期.
研究的目的:
- 研究母体甲状腺功能低下症和甲状腺自身免疫对胎儿内结构的影响.
- 为了确定胎儿大脑关键参数的潜在变化.
主要方法:
- 对153名孕妇 (18-24周怀孕) 的前性病例控制研究.
- 参与者被分为:带有抗体的甲状腺功能低下症,没有抗体的甲状腺功能低下症和对照组.
- 超声波测量胎儿的后侧心室 (PLV),洞腔隔膜透明度 (CSP),大水 (CM),丘脑和跨大脑直径 (TCD).
主要成果:
- 与对照组相比,抗体低甲状腺症组的胎儿PLV和乳腺体测量明显较小 (p <0.05).
- 在大多数其他生物识别参数中没有发现显著差异.
- 孕产妇甲状腺功能低下症组的超重/肥胖率较高.
结论:
- 孕产妇的甲状腺功能低下和甲状腺自身抗体与胎儿大脑结构的微妙变化有关.
- 具体来说,在怀孕中期,观察到泰拉马斯和PLV的变化.
- 需要进一步的研究来了解长期影响.
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