在没有肺动脉高血压的情况下患有系统性硬化症的患者中,心脏参与和心力衰竭的分期
Maria Isilda Oliveira1,2,3, Bruno Bragança4,5, José Rodrigues Gomes6
1Pulmonary Vascular Disease Unit, Department of Cardiology, Unidade Local de Saúde de Santo António, 4099-001 Porto, Portugal.
系统性硬化症患者经常患有临床前和症状性心力衰竭 (HF),通常与疾病严重程度和年龄有关. 像6分钟步行测试这样的功能测试有助于评估HF风险.
科学领域:
- 心脏病学 心脏病学
- 类风湿病学 类风湿病学
- 肺部病理学 肺部病理学
背景情况:
- 系统性硬化症 (SSc) 是一种自身免疫性疾病,导致纤维化和血管损伤,增加心力衰竭 (HF) 的风险.
- 在SSc患者中HF的患病率和病期需要进一步调查.
研究的目的:
- 分析SSc患者中HF的患病率和阶段.
- 为了确定HF阶段与临床,心声学,血液动力学和功能参数之间的关联.
主要方法:
- 对61名SSc患者 (不包括肺动脉高血压) 的横截面研究.
- 使用更新的指南对高频段的分类.
- 对临床,心声回声,血液动力学和功能能力数据 (6MWT,CPET) 的分析.
主要成果:
- 48%的人患有前症状高血压 (A/B阶段),38%的人患有症状高血压 (C阶段).
- HF的严重程度与年龄和多器官参与相关.
- 心声学异常和功能障碍 (降低6MWT,VO2峰值,增加VE / VCO2斜率) 是普遍存在的,并且与HF严重程度有关.
结论:
- 临床前和症状性HF在SSc中非常普遍.
- HF分期与SSc疾病的严重程度,年龄和心血管风险因素有关.
- 功能能力测试对于SSc患者的HF风险分层有价值.
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