精神分裂症中的心血管疾病标志物 在负面症状和缓解期期间
Okan Imre1, Gurkan Imre2, Mehmet Mustu3
1Department of Psychiatry, Faculty of Medicine, Karamanoglu Mehmetbey University, Karaman 70200, Turkey.
Journal of clinical medicine
|April 12, 2025
概括
精神分裂症患者,特别是缓解期患者,表现出心血管疾病风险标志物如甘油三和异位原体指数的升高. 早期监测精神分裂症的心血管风险因素对于及时干预至关重要.
科学领域:
- 精神病学和心脏病学
- 心血管疾病风险的生物标志物
背景情况:
- 精神分裂症与较高的心血管疾病 (CVD) 患病率有关.
- 在精神分裂症患者中早期发现心血管疾病风险对于预防策略至关重要.
研究的目的:
- 研究和比较精神分裂症患者心血管疾病 (CVD) 风险标志物 (负症状和缓解) 与健康对照.
- 为帮助早期发现精神分裂症患者无症状心血管疾病.
主要方法:
- 横截面病例控制研究涉及三个组:精神分裂症与负症状 (SCH-N,n:20),精神分裂症缓解 (SCH-R,n:23),和健康的对照 (HC,n:21).
- 评估的脂质特征,无菌原体指数 (AIP),甘油三糖 (TyG) 指数,卡斯特利风险指数-1 (CRI-I),卡斯特利风险指数-2 (CRI-II) 和无菌原体系数 (AC).
- 统计分析包括正常性测试,ANOVA,克鲁斯卡尔-瓦利斯,邦费罗尼和恩-邦费罗尼测试 (p <0.05显著性).
主要成果:
- 与健康对照组 (HC) 相比,缓解中的精神分裂症 (SCH-R) 组显示了甘油三 (TGs),TyG指数,AIP,CRI-I,CRI-II和AC在统计学上显著增加 (p <0.001大多数).
- 这些发现表明精神分裂症患者心血管风险概况较高,特别是在缓解期.
结论:
- 精神分裂症患者表现出显著改变的心血管风险标志物.
- 提升的TGs,TyG指数,AIP,CRI-I,CRI-II和AC表明精神分裂症中心血管疾病风险增加.
- 强烈建议对精神分裂症患者的心血管风险因素进行密切监测和早期干预.
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