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术后低甲状腺症的患病率和预测因素:一个多中心观察性研究

Reem J Al Argan^1,2, Dania M Alkhafaji^1,2, Shaya Y AlQahtani^1,3

¹Department of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 31441, Eastern Province, Saudi Arabia.

Journal of clinical medicine

|April 12, 2025

概括

甲状腺外科手术后的甲状腺缺血症 (HPT) 是常见的,影响35.3%的患者. 手术程度和低副甲状腺激素 (PTH) 水平预测HPT,中央淋巴结解剖强烈预测永久HPT.

科学领域:

内分泌学在内分泌学.
手术瘤学手术瘤学
神经外科神经外科

背景情况:

甲状腺外科手术后的甲状腺缺血症 (HPT) 是一个常见的并发症,可能导致长期的发病率.
甲状腺手术后HPT的发生率可以高达29%.

研究的目的:

调查甲状腺手术后HPT的患病率和预测因素.
确定与暂时性和永久性HPT相关的因素.

主要方法:

这是一项追溯的多中心观察性研究,包括在2016年至2022年期间接受甲状腺手术的679名患者.
对人口统计数据,手术细节,病理学和术后和副甲状腺激素 (PTH) 水平的分析.
多变量分析以确定HPT的独立预测因子,统计显著性设置为p < 0.05.

主要成果:

在35.3%的病例中发生了HPT (228/679),其中81%是暂时的,19%是永久的.
总甲状腺切除术 (OR 2.7),完成甲状腺切除术 (OR 8.4) 和低的立即术后PTH (OR 3.1) 预测了HPT.
中枢淋巴结解剖 (CLND; OR 4.03) 和低术后PTH (OR 2.56) 预测了永久的HPT.

结论:

手术程度和低术后PTH水平是HPT的关键预测因素.
CLND和低术后PTH水平是永久性HPT最强的预测因素.
风险评估和早期PTH水平测量可以帮助最大限度地减少HPT发生和指导干预.

关键词:

维生素D 维生素D是一种维生素.低血症是指低血症.甲状腺过敏症 (hypoparathyroidism) 是一种严重的疾病.脑叶切除术 (lobectomy) 是一个脑叶切除术.甲状腺上腺激素水平水平永久的永久的永久的永久的血清中的是血清中的.完全的甲状腺切除术这是一个短暂的过渡.

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