维生素D和具有鼻息肉的慢性鼻炎:叙述性审查和前景
Adrien Philippart1,2, Philippe Eloy3
1Department of Oto-Rhino-Laryngology & Head and Neck Surgery, Saint-Jean Clinics, Boulevard du Jardin Botanique 32, 1000 Brussels, Belgium.
Journal of clinical medicine
|April 12, 2025
概括
维生素D可以通过调节炎症来改善具有鼻息肉的慢性鼻炎 (CRSwNP). 需要进一步的研究,以了解其在鼻腔疾病和无性疾病中的作用.
科学领域:
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 内分泌学 在内分泌学.
背景情况:
- 带鼻息肉的慢性鼻炎 (CRSwNP) 是一种衰弱的疾病,其特征是鼻息肉,Th2炎症和生活质量受损.
- 目前的治疗方法,包括类固醇和生物药物,提供有限的疾病控制,突出需要新的治疗策略.
- 低维生素D水平越来越多地与较差的CRSwNP结果有关,这表明这种维生素在疾病发病过程中的潜在作用.
研究的目的:
- 审查目前关于维生素D在CRSwNP相关的全身和局部炎症中的作用的研究.
- 探索维生素D补充对CRSwNP管理的潜在治疗影响.
- 为了为未来的研究提供一个基础,对维生素D缺乏在鼻腔和形疾病.
主要方法:
- 对维生素D和CRSwNP的现有文献进行系统审查.
- 在CRSwNP的背景下,对研究维生素D对免疫反应,纤维细胞活性和上皮质完整性的影响的研究分析.
- 关于CRSwNP患者维生素D补充试验的综合证据.
主要成果:
- 新出现的证据表明,维生素D影响了与CRSwNP相关的关键途径,包括免疫调节,纤维细胞功能和上皮屏障完整性.
- 研究表明,维生素D补充剂可以改善CRSwNP和维生素D缺乏症患者的症状.
- 维生素D影响CRSwNP病变的确切机制需要进一步阐明.
结论:
- 维生素D有潜力作为CRSwNP的辅助疗法,特别是在缺乏的个体中.
- 需要进一步的研究来澄清作用机制,并优化维生素D在CRSwNP中的治疗应用.
- 了解维生素D的作用可以为管理鼻腔和相关的形疾病的更广泛的策略提供信息.
更多相关视频
11:54Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
Published on: January 21, 2018
29.8K
04:05Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
Published on: December 20, 2024
314
相关概念视频
01:23Chronic Pharyngitis
661
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
661
01:17Drugs Used in Lower Respiratory Disorders: Overview
271
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
271
01:24Cystic Fibrosis: Management
110
Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
Sinus disease and chronic...
110
01:16Drugs Used in Upper Respiratory Disorders: Overview
143
Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
143
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.7K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.7K
01:29Chronic Obstructive Pulmonary Disease-V: Management
2.5K
Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
Smoking Cessation
2.5K