肠-大脑-微生物群连接及其在自闭症谱系障碍中的作用
Ewelina Młynarska1, Ewelina Barszcz1, Emilian Budny1
1Department of Nephrocardiology, Medical University of Lodz, ul. Zeromskiego 113, 90-549 Lodz, Poland.
Nutrients
|April 12, 2025
概括
肠道微生物群的变化与自闭症谱系障碍 (ASD) 症状有关. 诸如益生菌和便微生物群移植 (FMT) 等疗法是有前途的,但个性化的方法是有效的ASD管理的关键.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 遗传学 是一个遗传学.
背景情况:
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况,原因不明.
- 肠道微生物群在肠-大脑轴 (GBA) 中发挥着至关重要的作用,影响神经系统的发育和行为.
- 微生物群失衡 (失生症) 与ASD的行为和胃肠道 (GI) 症状有关.
研究的目的:
- 审查肠道微生物群在ASD中的作用.
- 探索潜在的治疗干预措施,以肠道微生物群为目标,用于ASD管理.
- 强调需要个性化的治疗策略在ASD.
主要方法:
- 这篇叙事综述综合了当前关于肠道微生物群和ASD的研究.
- 它检查了微生物群影响GBA的机制.
- 它讨论了饮食干预,益生菌和便微生物群移植 (FMT) 作为潜在的治疗方法.
主要成果:
- 肠道微生物群组成和多样性的改变与ASD严重程度有关.
- 饮食变化,益生菌和FMT显示出改善ASD的胃肠道和行为症状的潜力.
- FMT在增强微生物多样性和减轻ASD症状方面表现出有希望的结果.
结论:
- 肠道微生物群是ASD病因的一个重要因素,是创新疗法的目标.
- 个性化治疗策略,考虑到个体微生物群的特征和遗传学,对于有效的ASD干预至关重要.
- 需要进一步的研究来确定肠道向治疗ASD的长期疗效和安全性.
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