细菌菌株特异性治疗潜力:一个系统的范围审查
Oranut Chatsirisakul1, Natasha Leenabanchong2, Yada Siripaopradit1
1Faculty of Medicine, Chulalongkorn University, Rama IV Rd., Pathumwan, Bangkok 10330, Thailand.
Nutrients
|April 12, 2025
概括
特定的Lactiplantibacillus plantarum (L. plantarum) 菌株提供有针对性的健康益处,包括改善肠道健康,免疫调节和口腔护理. 建议在临床整合方面进行进一步的研究.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 口腔健康 口腔健康
- 妇女健康 妇女健康
背景情况:
- 益生菌,特别是Lactiplantibacillus plantarum (L. plantarum),越来越多地被认为具有健康益处.
- 了解菌株特异性影响对于优化治疗应用至关重要.
- 需要进行系统审查,以巩固目前关于L. plantarum菌株的证据.
研究的目的:
- 评估特定的L. plantarum菌株的治疗潜力和临床益处.
- 为了确定各种人类健康状况的菌株特异性影响.
- 为了指导L. plantarum在医疗保健中的临床应用.
主要方法:
- 按照PRISMA-ScR指南进行系统范围审查.
- 用于研究选择的PICO框架.
- 在PubMed和Embase数据库中进行全面的文献搜索,截至2023年12月.
主要成果:
- 对69项研究的分析揭示了L. plantarum菌株的各种益处.
- L. plantarum 299v:改善了胃肠道症状,口腔健康和减少了炎症.
- L. plantarum IS-10506:具有免疫调节作用,特别是在阿托皮性皮肤炎中.
- L. plantarum LB931:减少了致病菌的殖民,并支持了阴道健康.
- L. plantarum CCFM8724:有可能减少幼儿.
结论:
- 植物菌株Lactiplantibacillus plantarum对特定的健康问题具有显著的治疗潜力.
- 有证据支持将某些L. plantarum菌株纳入临床实践.
- 进一步的研究对于确定最佳剂量,机制和长期安全性至关重要.
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