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用3D打印的聚卡普罗拉克/氧亚帕生物脚手架用于骨再生.

Feng-Ze Wang1, Shuo Liu1, Min Gao2

  • 1Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology and National Center for Stomatology and National Clinical Research Center for Oral Diseases and National Engineering Research Center of Oral Biomaterials and Digital Medical Devices and Beijing Key Laboratory of Digital Stomatology and NHC Key Laboratory of Digital Stomatology and NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing 100081, China.

Polymers
|April 12, 2025
PubMed
概括
此摘要是机器生成的。

使用3D打印的生物骨架为传统移植提供了替代方案. 一个55%的灌装密度的状腺支架显示了骨缺陷修复的最佳特性.

关键词:
仿生脚手架 仿生脚手架 仿生脚手架骨的形成 骨的形成胃腺瘤 (Gyroid) 是一种疾病.氧亚帕 (HA) 是一种氧亚帕.聚卡普罗拉克 (PCL) 是一种三维打印是三维打印的一种方式.

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科学领域:

  • 生物材料工程 生物材料工程
  • 组织工程是组织工程.
  • 添加剂制造 添加剂制造 添加剂制造

背景情况:

  • 自主骨移植有局限性,包括捐赠者部位的发病率和材料稀缺性.
  • 三维 (3D) 打印,特别是化沉积建模 (FDM),为制造生物骨架提供了一个有前途的方法.
  • 甲状腺结构的支架对于模仿无骨架构具有兴趣,但它们的FDM制造和最佳设计参数需要进一步调查.

研究的目的:

  • 通过使用FDM,研究聚烯/酸 (PCL/HA) 陀螺脚手架的制造和性能.
  • 为了确定灌装密度对这些支架孔径,水友性,机械性能和体外生物性能的影响.
  • 为了确定一个最佳的状腺支架设计用于骨缺陷修复.

主要方法:

  • 聚烯酸/酸 (PCL/HA) 脚手架是使用FDM制造的,其填充密度各不相同 (40-60%).
  • 使用了无溶剂的发光线制备方法.
  • 使用扫描电子显微镜 (SEM) 鉴定了支架的特征,并评估了它们的水性,机械性质和体外细胞反应 (性酸酶活性,沉积).

主要成果:

  • 所有制造的脚手架都展示了相互连接的多孔结构.
  • 填充密度为55%的脚手架呈现了465±63微米的最佳孔径.
  • 这种55%填充密度的脚手架表现出优越的水友性,与自然无骨骨相比的机械性能,以及增强的细胞活动,包括桥梁,性酸酶 (ALP) 活动和盐沉积.

结论:

  • 灌装密度显著影响FDM制造的陀螺脚手架的性能.
  • 55%的灌装密度为PCL/HA陀螺脚手架提供了最佳的孔径,机械强度和生物性能.
  • 这些发现为通过FDM设计先进的状腺支架,用于骨再生应用提供了宝贵的见解.