在微尘暴露下,用生物聚合物重建人类皮肤等效的伤口愈合
Taeeun Kim1, Junwoo Lim1, Jaehyun Jeong1
1Department of Chemical Engineering, Soongsil University, 369, Sangdo-Ro, Ronjak-Gu, Seoul 06978, Republic of Korea.
Polymers
|April 12, 2025
概括
空气中的微尘显著损害了皮肤的伤口愈合,延迟了关闭和重新上皮质化的过程. 这项研究揭示了多环芳和微量金属等污染物通过引起炎症和氧化应激来破坏皮肤修复.
科学领域:
- 环境科学 环境科学
- 皮肤病学 皮肤病学
- 毒理学 毒理学 毒理学
背景情况:
- 空气中的微尘污染是众所周知的健康危害,影响呼吸道和皮肤健康.
- 微尘对皮肤伤口愈合过程的具体影响尚不清楚.
研究的目的:
- 为了研究微尘成分对人类皮肤伤口愈合的影响.
- 分析聚环芳 (PM10-PAHs) 和含有微量金属的微粒 (PM10-Trace) 对皮肤修复机制的影响.
主要方法:
- 使用人类皮肤等价物 (HSEs) 用原生物材料和皮肤细胞重建.
- 暴露的HSE用于模拟细尘化合物 (PM10-PAHs和PM10-Trace).
- 监测伤口关闭,重新上皮化,蛋白酶激活受体-1 (PAR1) 表达,炎症和氧化应激.
主要成果:
- 对细尘的暴露延迟了伤口关闭的时间是对照组的2-3倍,显著损害了再上皮质化.
- 微量金属颗粒对伤口愈合的抑制作用比PAHs更强.
- 观察到PAR1表达增加了161%,并增加了炎症和氧化应激,表明皮肤受损严重.
结论:
- 空气中的微尘大大扰乱了皮肤伤口修复过程.
- 诸如PAH和微量金属等污染物对皮肤的结构和功能完整性产生负面影响.
- 研究结果强调,需要制定战略来抵消空气污染对皮肤健康的有害影响.
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