相关实验视频

Updated: May 14, 2025

Neutrophil Extracellular Traps Generated by Low Density Neutrophils Obtained from Peritoneal Lavage Fluid Mediate Tumor Cell Growth and Attachment

Neutrophil Extracellular Traps Generated by Low Density Neutrophils Obtained from Peritoneal Lavage Fluid Mediate Tumor Cell Growth and Attachment

Published on: August 3, 2018

中性细胞外细胞陷在肝损伤期间调解肝细胞的病理生理学

Ki M Mak¹, Aditya C Shekhar¹, Selena Y Ding¹

¹Department of Medical Education and Center for Anatomy and Functional Morphology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Anatomical record (Hoboken, N.J. : 2007)

|April 12, 2025

概括

中性细胞细胞外陷 (NETs) 对于病原体防御至关重要,但过度形成可能导致肝损伤. 本综述探讨了NETs在肝细胞病理生理学和肝病进展中的作用.

科学领域:

免疫学免疫学免疫学
肝病学肝病学是一种肝病学.
细胞生物学细胞生物学

背景情况:

中性细胞外细胞陷 (NETs) 是对病原体清除的必不可少的先天免疫成分.
失调的NET形成和受损的清除有助于炎症和器官损伤,包括肝损伤.
NETs与非传染性炎症疾病和慢性肝病有关.

研究的目的:

审查NETs影响肝细胞病理生理学的机制,并加剧肝损伤.
检查NETs在肝脏缺血再输损伤,肝细胞癌和癌症转移中的作用.
在肝损伤期间调查肝细胞之间的NET介导交叉声,并确定未来的研究途径.

主要方法:

关于NET和肝损伤现有研究的文献综述.
对NET与肝细胞相互作用的分子机制的分析.
综合了在各种肝病背景下对NETs的发现.

主要成果:

NETs与肝细胞,库弗弗细胞,肝脏侧状内皮细胞和肝脏恒星细胞相互作用,改变其功能并促进肝脏损伤.
NET 在肝缺血再输损伤,肝细胞癌发展和转移中起着重要作用.
有证据表明,在受伤期间,NETs介导不同肝细胞类型之间的交叉声调.

结论:

过度的NET形成是通过与肝细胞的复杂相互作用导致肝损伤的关键驱动因素.
准NET可能为肝脏疾病,包括癌症提供治疗策略.
需要进一步的研究,以充分阐明NET介导的交叉通话及其治疗影响.

关键词:

癌症转移的转移.肝细胞癌是肝细胞癌.缺血性再注射损伤的伤害中性粒细胞外细胞陷肝细胞的病理生理学

更多相关视频

Morphological and Compositional Analysis of Neutrophil Extracellular Traps Induced by Microbial and Chemical Stimuli

Morphological and Compositional Analysis of Neutrophil Extracellular Traps Induced by Microbial and Chemical Stimuli

Published on: November 4, 2022

Author Spotlight: Neutrophil Extracellular Traps Imaging in Human and Mouse Tissues

Author Spotlight: Neutrophil Extracellular Traps Imaging in Human and Mouse Tissues

Published on: August 18, 2023

相关概念视频

Liver Regeneration

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...

Phases of Wound Repair

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...

Inflammation

Inflammation

Liver Histology

Liver Histology

The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...