内部网络和互联网 功能连接的变化与口唇裂和 palatal 成年人的语言障碍相关的变化
Yingying Wang1,2, Chengdan Deng3,4, Hailong Li1,2
1Department of Radiology, Huaxi MR Research Center (HMRRC), Institution of Radiology and Medical Imaging, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
唇裂 (CLP) 改变了大脑的连接,影响了语言. 这项研究揭示了功能连接 (FC) 网络的广泛变化,将其与CLP患者的语言缺陷联系起来.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 语言病理学 语音病理学
背景情况:
- 唇裂 (CLP) 可以影响大脑功能并导致语言障碍.
- 在CLP中这些语言缺陷的潜在神经生物学机制尚未完全理解.
- 改变的功能连接 (FC) 被假设在与CLP相关的语言功能障碍中发挥作用.
研究的目的:
- 调查神经功能障碍在CLP对全脑功能连接 (FC) 的影响.
- 检查CLP患者中改变的大脑网络连接和语音功能之间的关系.
- 阐明与CLP相关的语言缺陷的神经生物学基础.
主要方法:
- 利用独立组件分析 (ICA) 识别了八个主要的大脑网络.
- 在33个CLP个人和41个控制器中,在网络内和网络之间比较了功能连接 (FC).
- 与语音评估分数相关的FC在群体间的差异.
主要成果:
- 在传感运动网络 (SMN),默认模式网络 (DMN) 和小脑网络 (CN) 中观察到降低了FC.
- 在执行控制网络 (ECN) 和其他几个网络 (如SMN-Auditory,DMN-Visual) 之间发现了增加的FC.
- 在改变的FC模式和语音评估得分之间发现了显著的相关性.
结论:
- 脑脊髓炎与大脑功能连接 (FC) 的广泛变化有关.
- 这些广泛的连接变化,特别是涉及传感器和默认模式网络,与语音缺陷有关.
- 大脑的可塑性和神经通路的改变有助于在CLP患者中观察到的语言障碍.
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