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Updated: May 14, 2025

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
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在NUDT15基因中的遗传变异将在癌症治疗中产生临床影响

Yazun Jarrar1, Maria Ghishan2, Fatima Khirfan2

  • 1Department of Basic Medical Sciences, Faculty of Medicine, Al-Balqa Applied University, Al-Salt, Jordan.

Drug metabolism and personalized therapy
|April 12, 2025
PubMed
概括

努迪克斯酶15 (NUDT15) 的遗传变异会影响氨酸药物代谢和毒性. 了解这些NUDT15变体对于个性化癌症治疗和改善患者治疗结果至关重要.

关键词:
在 NUDT1515 中.抗癌药物 抗癌药物 抗癌药物药物代谢 药物代谢个性化治疗是个性化的治疗.氨酸的衍生品 氨酸的衍生品

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Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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