在患有失眠的乳腺癌患者中,认知障碍的自然轨迹子类
Oxana Palesh1, Sarah E Braun1, Tina Truong2
1Virginia Commonwealth University, Massey Comprehensive Cancer Center, Richmond, Virginia, USA.
Cancer
|April 12, 2025
概括
与癌症相关的认知障碍 (CRCI) 在不同的患者子组中呈现,而不仅仅是二分法. 教育和种族等社会因素影响这些CRCI轨迹,表明需要有针对性的干预措施.
科学领域:
- 神经科学是一个神经科学.
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 与癌症相关的认知障碍 (CRCI) 传统上被视为二分法.
- 识别CRCI子类和生物标志物可以提高受影响患者的风险预测.
研究的目的:
- 为了确定与癌症相关的认知障碍 (CRCI) 轨迹的不同子组.
- 探索健康的社会决定因素对CRCI的潜在影响.
- 研究神经元衍生外体 (NDE) 作为CRCI的潜在生物标志物.
主要方法:
- 139名接受化疗的乳腺癌患者在12个月内被评估.
- 增长混合模型 (GMM) 根据认知性能轨迹确定了潜在的子组.
- 收集了外围血液进行神经元衍生外体组 (NDE) 分析.
主要成果:
- 随着时间的推移,平均认知表现显著改善 (p < .001).
- 转基因检测发现了三个不同的子组:稳定的高性能 (N=45),可变的低性能 (N=15) 和改善平均性能 (N=79).
- 较低的教育程度和较高的种族/民族少数群体比例与可变的低绩效子组有关. 在NDE方面没有发现任何显著差异.
结论:
- 存在多个纵向CRCI轨迹,受教育和种族/种族等社会决定因素的影响.
- 应考虑对高风险CRCI患者进行干预.
- 对新型CRCI生物标志物的进一步研究是有必要的.
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