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Updated: May 14, 2025

CRISPR-Mediated Reorganization of Chromatin Loop Structure
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CRISPR-Mediated Reorganization of Chromatin Loop Structure

Published on: September 14, 2018

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一个特定的多能性相关的eRNA通过塑造表观遗传景观和稳定增强剂-促进剂相互作用来控制Nanog的位置

Mariella Cuomo1,2, Davide Costabile2,3, Rosa Della Monica1,2

  • 1Department of Molecular Medicine and Medical Biotechnologies, University of Naples "Federico II", Via S. Pansini 5, Naples 80131, Italy.

Nucleic acids research
|April 12, 2025
PubMed
概括

来自Nanog超级增强剂的增强器RNA (eRNA) 对于维持小鼠胚胎干细胞 (mESC) 的多能性至关重要. -5KNAR eRNA稳定了纳诺基位点和凝聚复合体,防止了分化.

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