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Updated: May 14, 2025

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage
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Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage

Published on: January 31, 2018

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聚ADP-ribose) 在DNA损伤反应中作为甲基转移酶METTL3/14复合物的支架

Claudia Gonzalez-Leal1,2, Jin Cai1,2, Bram A F J de Groot3

  • 1Department of Physiological Chemistry, Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Planegg - Martinsried, Germany.

Nucleic acids research
|April 12, 2025
PubMed
概括

聚ADP-核糖 (PAR) 和RNA动态影响DNA修复. 研究了METTL3/14复合体对DNA损伤的招募及其在修复中的作用,揭示了结合METTL3和PARP抑制剂用于癌症治疗的潜在治疗策略.

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Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues

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