器官功能障碍对儿科高血的结果的影响:一项回顾性观察性研究
Ayumi Mihara1, Kentaro Nishi2, Itaru Hayakawa3
1Center for Postgraduate Education and Training, National Center for Child Health and Development (NCCHD), 2-10-1 Okura, Setagaya-Ku, Tokyo, Japan.
Pediatric nephrology (Berlin, Germany)
|April 12, 2025
概括
儿科高血,在复杂病例中经常在医院获得,与死亡率有关. 器官功能障碍的数量是这些儿童死亡的关键预测因素.
科学领域:
- 儿科重症监护医药 儿科重症监护医药
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床流行病学临床流行病学
背景情况:
- 儿童的高血与死亡率的增加有关.
- 儿科高血症的具体临床因素和结果需要进一步阐明.
研究的目的:
- 阐明儿科高血的临床特征.
- 确定儿科高血死亡的预后因素,包括器官功能障碍的作用.
主要方法:
- 对儿科患者 (18岁以下) 的回顾性观察研究,血清≥150 mmol/L.
- 对患者人口统计,临床过程,死亡率和内出血的分析.
- 卡普兰-梅尔和考克斯对生存和风险因素的比例危险分析.
主要成果:
- 116名儿科患者 (1.2%) 患有高血症,91%患有慢性疾病和医院获得的病例.
- 药物使用率高 (85%),静脉注射液体 (80%),在发病前没有人使用 (63%).
- 180天的生存率为81.9%. 四个或更多的器官功能障碍显著预测死亡 (OR 5.83).
- 两名患者 (2%) 发展出新的皮肤下血液瘤.
结论:
- 儿科高血症主要影响医疗复杂的儿童,并且经常在医院获得.
- 器官功能障碍的程度是儿科高血症死亡率的重要预测因素.
- 了解这些因素可以帮助风险分层和风险管理.
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