相关实验视频

Updated: May 14, 2025

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

来自小面部/头皮皮肤状癌的延迟区域转移:结果和预测因素

Courtney B Shires¹, John D Boughter², Christopher P Golembeski³

¹West Cancer Center, Germantown, TN, USA. cshires1@gmail.com.

Archives of dermatological research

|April 12, 2025

概括

围神经侵袭是面部和头皮皮肤状细胞癌 (CSCC) 延迟转移的关键预测因素. 这一发现表明,小CSCC与PNI的预防性部治疗可能是有益的.

科学领域:

在瘤学瘤学.
皮肤病学皮肤病学
头部和部手术头部和部手术

背景情况:

面部和头皮的皮肤状细胞癌 (CSCC) 通常具有良好的预后.
在脸部/头皮的CSCC中延迟区域转移与患者的不良结果有关.
预防性部治疗不是面部/头皮早期 (T1-T2) CSCC 的标准.

研究的目的:

为了确定面部和头皮的CSCC中延迟区域转移的预测因素,其尺寸小于4厘米.
为了评估与晚期宫淋巴结复发相关的因素,在CSCC患者.

主要方法:

对2012-2018年医疗记录的回顾性分析.
在初始诊断后至少6个月内,包括被诊断为头皮/脸部CSCC区域转移的患者.
专注于在高等学术头诊所接受治疗的患者.

主要成果:

50名患有脸部/头皮CSCC的男性患者出现了延迟的宫淋巴结转移.
头皮,脸和额头是受影响最严重的区域.
主要瘤中的围神经入侵 (PNI) 是延迟部淋巴结复发的唯一预测因素;瘤大小,深度和淋巴血管入侵没有关联.

结论:

周围神经侵入 (PNI) 是面部和头皮的CSCC中延迟区域淋巴结转移的唯一确定的预测因素.
应使用PNI将小型CSCC升级到T3.
应强烈考虑预防性部治疗小头皮/面部CSCC与PNI,特别是在免疫治疗的进步.

关键词:

宫转移的发生.延迟的转移延迟的转移面对面的面对面的面对面的面对面头部和部的情况.免疫治疗是一种免疫疗法.周围神经的入侵.预测预后预测预测头发皮肤头发皮肤皮肤癌是一种皮肤癌.状细胞癌瘤是一种状细胞癌.

更多相关视频

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

Published on: January 5, 2017

相关概念视频

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...