在中国骨质发育不完善症患者的听力损失
Yuan Tian1, Yanxuan Shao1, Yazhao Mei1
1Department of Osteoporosis and Bone Disease, Shanghai Clinical Research Center of Bone Disease, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
概括
听力损失在中国患者中很常见,这些患者患有骨质发育不完善 (OI),骨脆弱性疾病. 该研究发现,随着年龄的增长,听力损失的患病率和严重程度会增加,需要早期的听力学监测.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 遗传学 是一个遗传学.
- 听力学 听力学是指听力学.
背景情况:
- 骨质变生不完美 (Osteogenesis Imperfecta,简称OI) 是一种遗传性疾病,其特征是骨脆弱.
- 听力损失是OI患者认可的骨外表现.
- 中国OI患者的听力学概况需要详细描述.
研究的目的:
- 调查和描述一组被诊断患有骨质发育不完善的中国患者的听力学发现.
- 为了确定与OI相关的听力损失的患病率和类型,在这个人群中.
- 探索OI患者的年龄和听力损失进展之间的关系.
主要方法:
- 共有76名OI患者 (4-77岁) 接受了全面的听力测量评估.
- 评估包括纯音调听力测量 (PTA),声学入口测量和扭曲产品音声发射 (DPOAEs).
- 患者按年龄 (儿童与成人) 和听力损失类型 (正常,导电,神经传感,混合) 分层.
主要成果:
- 纯音调听力测试显示,39%的被评估的耳朵有听力损失,并确定了导电性,感应神经和混合类型.
- tympanometry 显示了 tympanogram 类型和听力损失之间存在显著的关联.
- 扭曲产品的耳声辐射主要在带有神经感应和混合听力损失的耳朵中异常,年龄与听力损失的类型和严重程度有显著的相关性.
结论:
- 听力损失是患有骨质发育不完善的中国患者中普遍存在和进展的疾病.
- 在这个OI队列中,听力损失的患病率和严重程度与年龄相关的显著增加.
- 建立基线听力和实施定期的听力学随访对于OI患者的及时干预至关重要.
相关概念视频
01:31Hearing
51.3K
When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
51.3K
01:13The Cochlea
44.0K
The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
44.0K
01:11The Auditory Ossicles
1.4K
The auditory ossicles of the middle ear transmit sounds from the air as vibrations to the fluid-filled cochlea. The auditory ossicles consist of two malleus (hammer) bones, two incus (anvil) bones, and two stapes (stirrups), one on each side. These bones develop during the fetal stage and are the ones to ossify first. They are fully mature at birth and do not grow afterward.
The aptly named stapes look very much like a stirrup. The three ossicles are unique to mammals, and each plays a role in...
The aptly named stapes look very much like a stirrup. The three ossicles are unique to mammals, and each plays a role in...
1.4K
01:22Hair Cells
39.4K
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
39.4K