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Updated: May 14, 2025

Visualizing Surface T-Cell Receptor Dynamics Four-Dimensionally Using Lattice Light-Sheet Microscopy
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分析纳米级拓图 (PAINT) 数据中的点积累,以破译T细胞受体集群信号

Shirin Ansari1, James C Walsh1, Jesse Goyette2

  • 1Department of Molecular Medicine, School of Biomedical Sciences, University of New South Wales, Sydney, NSW, Australia.

Methods in molecular biology (Clifton, N.J.)
|April 12, 2025
PubMed
概括

这项研究引入了分析PAINT数据以量化T细胞受体 (TCR) 纳米集群的新管道. 这种方法增强了对T细胞激活过程中的分子事件的理解.

关键词:
这就是DNA-PAINT.蛋白质涂料是一种蛋白质涂料.超高分辨率显微镜的使用方法T细胞受体受体的 T 细胞受体.在TCR中,可以使用TCR.在TCR纳米集群中,TCR纳米集群是

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T Cell Activation and Clonal Selection01:22

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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