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Updated: May 11, 2026

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聚烯微塑料通过高脂肪饮食小鼠的肠道微生物群-脂肪组织交叉破坏棕色和色脂肪细胞功能

Guangning Kou¹, Shuai Yao², Amin Ullah³

¹Centre for Nutritional Ecology and Centre for Sport Nutrition and Health, Zhengzhou University, Zhengzhou 450001, China; Department of Nutrition and Food Hygiene, School of Public Health, Zhengzhou University, Zhengzhou 450001, China.

Journal of hazardous materials

|April 12, 2025

概括

微塑料 (MP) 破坏肠道微生物群,导致脂质积累,并减少小鼠的能量消耗. 这项研究揭示了MP如何损害棕色和色脂肪细胞的功能,影响肥胖.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
代谢过程中的代谢.

背景情况:

微塑料 (MP) 是广泛存在的环境污染物,带来了新的健康问题.
众议员对棕色和色脂肪细胞的影响,对于能源支出至关重要,仍然在很大程度上是未知的,特别是在肥胖症中.

研究的目的:

研究微塑料对棕色和色脂肪细胞功能的影响,以饮食引起的肥胖为背景.
阐明MPs影响能量代谢的潜在机制,包括肠道微生物群的改变.

主要方法:

给C57BL/6J小鼠食高脂肪饮食 (HFD),有或没有MP,持续12周.
分析包括肠道微生物群分析,便微生物群移植和代谢学.
评估了棕色脂肪组织 (BAT) 和 inguinal 白色脂肪组织 (iWAT) 的热生功能.

主要成果:

暴露于MP的HFD小鼠显示脂质积累增加,能量消耗减少.
在BAT和iWAT中,MPs诱导了肠道功能障碍和发热功能障碍.
来自暴露于MP的小鼠的便微生物群移植复制了受体的脂质积累和能量支出赤字.

结论:

微塑料通过改变肠道微生物群的组成,诱导棕色和白色脂肪组织的热生成功能障碍.
国会议员破坏胃肠道微生物群,导致代谢功能障碍,并可能加剧肥胖.

关键词:

布朗宁是什么意思布朗宁是什么意思我们的肠道微生物群.有高脂肪的饮食.微塑料是一种微塑料.热生成功能热生成功能

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