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多种方法分析揭示了Shugan Xiaozhi蒸可以防止与代谢功能障碍相关的脂肪肝炎的机制

Shuai Wang¹, Ruili Du², Jiahui Liu³

¹Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau 999078, PR China; Department of Hepatology, the Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, No. 15, Yingchun Road, Luohu District, Guangdong 518033, PR China; Shenzhen Key Laboratory of Liver Diseases of Chinese Medicine, No. 15, Yingchun Road, Luohu District, Guangdong, 518033, PR China.

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概括

舒甘小 (SGXZ) 有效地通过调节铁亡来治疗与代谢功能障碍相关的脂肪肝炎 (MASH). 这种传统中医药通过向p53/SLC7A11/GPX4通路来改善肝脏健康,减少细胞死亡和炎症.

科学领域:

肝病学肝病学是一种肝病学.
药理学药理学是指药理学的学科.
传统中国医药传统中国医药

背景情况:

代谢功能障碍相关的脂肪肝炎 (MASH) 是一种严重的肝病,治疗选择有限.
传统中医药中的Shugan Xiaozhi (SGXZ) ,在MASH治疗中显示出有效性,但其潜在的机制需要阐明.

研究的目的:

通过多组学和实验验证,研究MASH中SGXZ脱的治疗机制.
探索SGXZ作为MASH治疗的潜力.

主要方法:

超高性能液体染色学-电喷射电离-质谱学 (UPLC-ESI-MS) 确定了SGXZ的活性成分.
组织病理学分析 (PAS,PSR,油红色O染色) 和多组学 (蛋白质组学,转录组学) 在MASH小鼠模型中使用.
机制验证包括TUNEL,西部斑,IHC,TEM,免疫光,分子对接和动力学模拟.

主要成果:

SGXZ蒸改善了MASH组织病理学,肝功能和脂质/纤维化指标.
多基因组数据显示,铁化是SGXZ脱调节的关键途径.
治疗减少了细胞死亡,炎症,氧化应激,并恢复了线粒体功能,改善了铁代谢和激活Xc-系统.

结论:

SGXZ蒸对MASH具有显著的治疗效果.
该机制涉及调节p53/SLC7A11/GPX4通路,以减轻MASH中的铁亡.

关键词:

铁性化 (ferroptosis) 是一种铁的代谢铁的代谢脂质过氧化是一种过氧化.与代谢功能障碍相关的脂肪肝炎.舒甘小子的蒸煮剂舒甘小子的蒸 Xc- 系统系统.p53/SLC7A11/GPX4 路径中的一个.

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Enzyme Inhibition

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