甲基库尔库通过调节SPP1/CD44轴,缓解结直肠瘤发生,并防止M2瘤相关的巨细胞两极分化

甲基库尔库通过调节SPP1/CD44轴,缓解结直肠瘤发生,并防止M2瘤相关的巨细胞两极分化

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Mengting Zhou¹, Rui Li², Guiyun Lian³

¹School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Translational Chinese Medicine Key Laboratory of Sichuan, Sichuan-Chongqing Joint Key Laboratory of Innovation of New Drugs of Traditional Chinese Medicine, Sichuan Institute for Translational Chinese Medicine, Sichuan Academy of Chinese Medicine Sciences, Chengdu, 610041, China; Translational Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

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|April 12, 2025

概括

四基库 (THC) 通过向分泌的蛋白1 (SPP1) /CD44轴,对抗结肠直肠癌 (CRC). 这种作用抑制了M2巨细胞的两极化和ERK信号传递,最终抑制了CRC的进展,并调节了瘤的微环境.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

分泌的蛋白1 (SPP1) 涉及结直肠癌 (CRC) 的进展和M2巨细胞的两极分化,促进免疫逃避.
水库尔库 (THC) 显示出缓解CRC的潜力,但其潜在机制需要阐明.

研究的目的:

研究THC如何调节SPP1/CD44轴以抑制M2极化和抑制CRC发展.

主要方法:

使用阿佐西甲/德克斯硫酸 (AOM/DSS) 诱导的小鼠模型来评估THC的抗CRC作用.
采用转录基因组测序来识别THC在CRC中的关键标.
评估了THC对CRC细胞和瘤巨细胞相互作用的影响,使用共同培养模型,CCK-8,殖民地形成,迁移测定,免疫光和流细胞计.

主要成果:

在小鼠中,THC显著抑制了CRC的发展,改善了病理症状和炎症标志物.
THC抑制了CRC细胞的增殖,迁移和殖民地形成,同时增强了细胞亡.
转录组分析显示SPP1是关键标;THC通过准SPP1/CD44轴抑制CRC,抑制ERK信号传递和M2巨细胞两极分化.

结论:

SPP1对于维持M2巨细胞表型和促进CRC细胞增殖至关重要.
THC通过准SPP1/CD44轴,抑制ERK信号传递和M2类巨细胞转化,从而调节瘤免疫微环境,从而产生抗CRC作用.

关键词:

在CRC中,CRC就是CRC.通过ERK路径.M2与瘤相关的巨细胞在SPP1/CD44中使用.在这里,我们可以看到THCTHCTH.

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