新型成人特异性肺炎球菌联合疫苗的预期影响
R Joshi1, H T Ayele1, K D Johnson1
1Merck & Co., Inc., Rahway, NJ, USA.
Vaccine
|April 12, 2025
概括
一种新的成人疫苗V116为侵入性肺炎球菌病 (IPD) 提供了比PCV20更高的血清型覆盖率. 预计V116将在65岁及以上的成年人中预防更多的IPD病例.
科学领域:
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 侵袭性肺炎球菌病 (IPD) 发病率在成年人中仍然很高,尽管儿科肺炎球菌合疫苗 (PCV) 的减少.
- 成人疫苗接种策略对于控制IPD负担至关重要.
研究的目的:
- 为了比较V116的血清型覆盖率和IPD发病率,这是一种针对成年人的新型PCV,与成年人中的其他许可PCV相比.
- 评估V116对预防老年人IPD病例的潜在影响.
主要方法:
- 利用来自七个国家的国家IPD监测数据 (美国,加拿大,英国,德国,法国,西班牙,澳大利亚).
- 在65岁以上 (或60岁以上) 的成年人中计算V116和PCV20血清型覆盖率.
- 评估了V116覆盖的血清型与其他PCV的IPD发病率,估计了在美国预防的潜在病例.
主要成果:
- 与PCV20 (50%-66%) 相比,V116在65岁以上的成年人中显示出更高的IPD血清型覆盖率 (66%-88%).
- 由V116血型引起的IPD发病率在65岁以上的成年人中高于其他PCV的发病率.
- 在美国,V116有可能预防每年约8200例IPD病例,而PCV20的病例约为5000例.
结论:
- 在65岁及以上的成年人中,V116对IPD的血清型覆盖率明显高于PCV20.
- V116针对负责大多数成年IPD的血清型,预计可以预防比PCV20更多的病例.
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