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Updated: May 14, 2025

A Label-Free Segmentation Approach for Intravital Imaging of Mammary Tumor Microenvironment
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A Label-Free Segmentation Approach for Intravital Imaging of Mammary Tumor Microenvironment

Published on: May 24, 2022

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将空间转录和ECM成像3D结合起来,用于绘制瘤微环境中的细胞相互作用.

Tancredi Massimo Pentimalli1, Simon Schallenberg2, Daniel León-Periñán3

  • 1Laboratory for Systems Biology of Regulatory Elements, Berlin Institute for Medical Systems Biology (BIMSB), Max-Delbrück-Centrum for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin.

Cell systems
|April 12, 2025
PubMed
概括

这项研究整合了3D空间转录学和ECM成像来分析瘤微环境. 它通过详细描述细胞相互作用和肺癌中ECM重塑,揭示了治疗的可用药物标.

关键词:
在3D中,它是3D.细胞与细胞的相互作用.表皮细胞到介质细胞的过渡.细胞外矩阵是细胞外矩阵.不是小细胞肺癌的肺癌.个性化瘤学个性化瘤学第二波成像技术空间转录学 空间转录学系统医学系统医学瘤微环境是一个微环境.

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The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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