在腹腔透析结果和实践模式研究 (PDOPPS) 中,血清,腹腔透析相关腹腔炎和死亡率之间的关联
Isaac Teitelbaum1, Junhui Zhao2, Charlotte Tu2
1Division of Kidney Diseases and Hypertension, Department of Medicine, School of Medicine, University of Colorado Hospital, Aurora, Colorado.
概括
血清含量会影响腹膜透析患者的死亡率,但不会影响腹膜炎的风险. 在这项大型观察性研究中,较低和较高的水平与死亡率的增加有关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床流行病学临床流行病学
背景情况:
- 腹腔透析 (PD) 患者血清变化的临床影响尚不清楚.
- 了解这些关联对于优化患者护理和结果至关重要.
研究的目的:
- 为了研究血清水平与腹膜炎的风险和PD患者因任何原因的死亡率之间的关系.
- 评估使用icodextrin是否会改变这些关联.
主要方法:
- 在PDOPPS研究 (2014-2022) 中对23,707名PD患者进行的多中心观察队列研究.
- 在招生时血清水平被分类 (<135,135-137,138-139,140-141,≥142 mEq/L).
- 使用因果特异性危险模型,根据相关的共变量进行调整.
主要成果:
- 血清类别和PD相关炎风险之间没有发现显著的关联.
- 与140-141mEq/L的血清相比,<135mEq/L (AHR 1.45),135-137mEq/L (AHR 1.26) 和≥142mEq/L (AHR 1.16) 的水平与所有原因死亡率的增加有关.
- 这些关联在各个子组中都一致,并且不受icodextrin使用的影响.
结论:
- 血清的变化与死亡风险有关,但与PD患者的腹膜炎无关.
- 需要进一步的研究来阐明潜在的机制和潜在的治疗点.
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