怀孕期间母亲PM2.5暴露对大鼠后代心血管发育不良的影响
Shengying Yang1, Guiming Zhang2, Xinru Hong3
1Department of Obstetrics and Gynecology, Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, Sichuan Province, China; Department of Obstetrics and Gynecology, Dongfang Affiliated Hospital of Xiamen University, 900 Hospital of the Joint Logistics Team, Fuzhou, Fujian Province, China.
Reproductive toxicology (Elmsford, N.Y.)
|April 12, 2025
概括
孕妇在怀孕期间接触细颗粒物 (PM2.5) 可能会损害胎儿的心脏发育. 这项对大鼠的研究表明,暴露于PM2.5会改变关键的心脏因素,导致发育不良和代谢问题.
科学领域:
- 环境健康 环境健康
- 发展生物学 发展生物学
- 毒理学 毒理学 毒理学
背景情况:
- 流行病学研究将母体PM2.5暴露与胎儿心血管异常联系起来.
- 对这些机制的实验证据有限.
研究的目的:
- 为了研究母体PM2.5暴露对胎儿心血管发育的影响,在老鼠模型中.
- 探索潜在的分子机制.
主要方法:
- 孕妇大鼠被暴露在不同剂量的PM2.5 (0.2.6,5.5,11μg/d) 中.
- 心脏转录因子,血管标记物,氧化应激,亡和脂质代谢在新生儿的心脏和血清中进行了评估.
主要成果:
- 高剂量的PM2.5暴露显著降低了心脏转录因子 (Tbx2,Tbx20,Hand2,Gata6) 和血管标志物 (MMP9,TN-C,VEGF-A).
- 暴露于PM2.5增加了氧化应激标志物 (NF-κB,Bax/Bcl-2比率) 和脂质失调.
- 较低的PM2.5剂量也显示了特定标记物的显著变化.
结论:
- 在怀孕期间母亲的PM2.5暴露会诱导胎儿心血管发育不良.
- 机制包括心脏转录因子的改变,血管功能障碍,氧化应激,亡和脂质代谢异常.
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