在实验性脊髓损伤后,胰腺外分泌物的功能障碍
Emily N Blanke1, Gregory M Holmes2
1Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, United States of America; Department of Biology, Pennsylvania State University, York, PA 17403, United States of America.
Experimental neurology
|April 12, 2025
概括
脊髓损伤 (SCI) 破坏胰腺外分泌 (PES) 调节,影响消化,并可能导致胰腺功能障碍. 这项研究显示,经过实验性小鼠胸部SCI后,胰腺的阴道控制受损.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 身体生理学 身体生理学
背景情况:
- 胰腺外分功能障碍是脊髓损伤 (SCI) 患者诊断不足的并发症.
- 胰腺外分泌物 (PES) 的副交感控制涉及背部阴道综合体和胆囊托基宁 (CCK).
- 以前的研究表明,高胸部 (T3) SCI 降低了对像CCK和甲状腺激素释放激素 (TRH) 这样的肠道酸的阴道 afferent 敏感性.
研究的目的:
- 研究实验T3-SCI对大鼠胰腺外分泌物 (PES) 的影响.
- 确定SCI如何影响胰腺功能的阴道控制,以应对食和TRH刺激.
主要方法:
- 实验T3-SCI在老鼠中被诱导.
- 测量了胰腺外分泌物 (PES) 量和粉酶度.
- 刺激涉及输入双胞胎肠道的营养餐或中部TRH注射到阴道的背部运动核.
- 在一个单独的队列中评估了基础血清粉酶水平.
主要成果:
- 在T3-SCI后3周的老鼠中,基线PES体积较低.
- 在3周T3-SCI大鼠中,PES蛋白度在基线下降.
- 餐后PES蛋白度在3天和3周T3-SCI大鼠中升高.
- TRH微注射仅在3天T3-SCI大鼠中提高了PES蛋白度.
- 血清氨酶活性在3天T3-SCI大鼠中升高,并在3周保持升高.
结论:
- 实验T3-SCI破坏了胰腺外分泌的阴道调节.
- 这些干扰在伤害后的短期 (3天) 和长期 (3周) 期间都很明显.
- 这些发现表明,在SCI之后,阴道介导的内脏器官调节受到了更广泛的损害.
相关概念视频
Hormonal Regulation
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
Neurogenesis and Regeneration of Nervous Tissue
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
Cells and Secretions of the Pancreas
The pancreas, a vital organ within the abdominal cavity, plays dual roles in the digestive and endocrine systems, collaborating with exocrine and endocrine cells to maintain optimal digestion and blood sugar levels.
Exocrine function is carried out by acinar cells, organized into clusters known as acini. These cells contribute to digestion by releasing substantial quantities of enzyme-rich, alkaline digestive juices.
Concurrently, the dispersed clusters of endocrine cells throughout the...
Exocrine function is carried out by acinar cells, organized into clusters known as acini. These cells contribute to digestion by releasing substantial quantities of enzyme-rich, alkaline digestive juices.
Concurrently, the dispersed clusters of endocrine cells throughout the...
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion
The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are co-secreted in...
Insulin and C-peptide are co-secreted in...
Acute Pancreatitis II: Pathophysiology
The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
Chronic Pancreatitis II: Pathophysiology
Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...


