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Updated: May 13, 2025

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机械压力过载促进NF-κB/NLRP3介导的骨关节炎,通过Piezo1促进关节膜炎和纤维化

Likai Yu1, Di Tian1, Zishan Su1

  • 1Department of Orthopedics, Affiliated Hospital of Nanjing University of Chinese Medicine/ Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, Jiangsu, China; Key Laboratory for Metabolic Diseases in Chinese Medicine, First College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China.

Cellular signalling
|April 12, 2025
PubMed
概括

机械压力通过激活Piezo1通道驱动膝关节关节炎. 这导致通过NF-κB/NLRP3通路引起突膜炎和纤维化,突出显示Piezo1是KOA.的治疗标.

关键词:
膝关节骨关节炎是一种关节炎.机械应力 机械应力 机械应力在NLRP3中,NLRP3是NLRP3中的一个.这是一个Piezo1.这就是Synovium.

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