HPV 疫苗 - 预防 HPV 相关癌症的游戏改变者
John Dickson Calvin Devadasan1, Karthick Nithyanandhan1, Gnanadurai John Fletcher1
1Department of Clinical Virology, Christian Medical College, Vellore, India.
Indian journal of medical microbiology
|April 12, 2025
概括
预防性疫苗通过向人类乳头瘤病毒 (HPV) 来预防宫癌. 本综述详细介绍了当前的HPV疫苗及其机制,时间表和有效预防的成本.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 人类乳头瘤病毒 (HPV) 是全球宫癌的主要原因.
- 高风险的HPV基因型16/18负责至少70%的宫癌,主要发生在低至中等收入国家.
- 预防性疫苗接种对于预防HPV感染和随后的宫癌至关重要.
研究的目的:
- 审查目前的预防性HPV疫苗.
- 检查它们的作用机制,疫苗接种计划和相关成本.
- 为预防宫癌提供HPV疫苗领域的概述.
主要方法:
- 已批准的预防性HPV疫苗的文献审查.
- 基于L1蛋白和病毒样颗粒的疫苗机制分析.
- 疫苗接种计划和成本效益的比较评估.
主要成果:
- 目前已批准6种预防性HPV疫苗.
- 所有疫苗都针对HPV 16和18,预防大约70%的与HPV相关的宫前瘤.
- 疫苗通过L1蛋白病毒样颗粒诱导HPV类型特定的中和抗体.
结论:
- 目前的HPV疫苗在预防与HPV 16/18相关的宫前癌症方面是有效的.
- 了解疫苗机制,时间表和成本对于全球宫癌控制战略至关重要.
- 疫苗接种仍然是宫癌发病率的初级预防的基石.
更多相关视频
13:41Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012
12.3K
10:26RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
27.2K
相关概念视频
Cancer Vaccines
259
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
259
Cancer Prevention
6.0K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.0K
Vaccinations
43.0K
Overview
43.0K
Healthcare Associated Infections II: Preventive Measures
2.3K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.3K
Tumor Immunotherapy
404
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
404
Preventive Healthcare Services
947
Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
947
