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Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
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皮肤肝 perfusion 程序的麻醉特异性协议.

Daniel A Nahrwold1, Jinhong Liu1, Navindra Doobay2

  • 1H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL; University of South Florida Morsani College of Medicine, Tampa, FL.

Journal of cardiothoracic and vascular anesthesia
|April 12, 2025
PubMed
概括

透皮肝 perfusion (PHP) 提供了一个安全的麻醉方法,用于皮膜黑色素瘤肝转移. 在这个复杂的手术过程中,仔细的手术前评估和手术内管理是处理血液动力学变化的关键.

关键词:
麻醉是一种麻醉.凝血病是一种凝血病.梅尔法兰化通过皮肤的肝输液.阴膜性黑色素瘤是什么血管压缩器 血管压缩器静脉绕道 (Venovenous Bypass) 是一种静脉绕道.

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科学领域:

  • 肝病学 肝病学是一种肝病学.
  • 在瘤学瘤学.
  • 麻醉学 麻醉学

背景情况:

  • 透皮肝 perfusion (PHP) 越来越多地用于肝脏转移从毛膜黑色素瘤.
  • 作者的机构拥有丰富的经验,执行了200多个PHP程序.

研究的目的:

  • 评估通过皮肤输血肝脏 (PHP) 程序的麻醉安全性.
  • 突出PHP期间麻醉护理的挑战和管理策略.

主要方法:

  • 对200多种皮肤通肝输液 (PHP) 程序的麻醉管理的审查.
  • 对手术内血动力学波动和术后并发症的分析.

主要成果:

  • PHP程序具有有利的麻醉安全概况.
  • 显著的血压和心率波动发生在化疗和旁路治疗期间,通常需要血管压缩剂.
  • 手术后的管理包括血液制品用于凝血病和利尿剂用于液体过载.
  • 麻醉和手术相关的并发症很少见,但可能很严重.

结论:

  • 穿皮肝输液 (PHP) 通常在患有骨膜黑色素瘤肝转移的患者中耐受良好.
  • 麻醉特定的协议对于成功和安全的PHP程序至关重要.
  • 血动力学不稳定性和术后并发症的积极管理是必不可少的.