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Updated: May 13, 2025

A Macrophage Reporter Cell Assay to Examine Toll-Like Receptor-Mediated NF-kB/AP-1 Signaling on Adsorbed Protein Layers on Polymeric Surfaces
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A Macrophage Reporter Cell Assay to Examine Toll-Like Receptor-Mediated NF-kB/AP-1 Signaling on Adsorbed Protein Layers on Polymeric Surfaces

Published on: January 7, 2020

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突变的CEBPA通过缺陷的AP-1激活促进对炎症性压力的耐受性

Maria Cadefau-Fabregat1,2,3, Gerard Martínez-Cebrián1, Lucía Lorenzi1

  • 1Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain.

Nature communications
|April 12, 2025
PubMed
概括

在急性髓性白血病 (AML) 中,突变的CCAAT增强剂结合蛋白α (CEBPA) 产生一种改变炎症和压力反应的p30异型. 这影响了细胞因子分泌,并赋予了对炎症的抵抗力,揭示了潜在的AML脆弱性.

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