在焦虑障碍中的肠道微生物群
Mary I Butler1, Sarah Kittel-Schneider2,3,4, Jolana Wagner-Skacel5
1Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland. mary.butler@ucc.ie.
Current psychiatry reports
|April 12, 2025
概括
肠道微生物组可能会影响诸如GAD之类的焦虑症. 特定的细菌可能会被耗尽,虽然益生菌有前途,但需要更多的研究以有效的微生物组为基础的焦虑治疗.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 精神病学是一个精神病学.
背景情况:
- 肠道微生物组在宿主生理和行为中起着至关重要的作用.
- 新出现的证据表明,肠道微生物和心理健康之间存在联系,包括焦虑症.
研究的目的:
- 审查有关肠道微生物组在泛性焦虑障碍 (GAD),恐慌障碍 (PD), agoraphobia 和社会焦虑障碍 (SAD) 中的作用的当前文献.
- 在焦虑中探索与微生物组-肠-大脑轴相关的潜在机制和因果关系.
- 评估基于微生物组的干预措施对焦虑障碍的疗效.
主要方法:
- 对有关肠道微生物组组成和功能在焦虑障碍中的现有研究进行系统审查.
- 对有关特定细菌种类及其与焦虑相关的发现进行分析.
- 评估益生菌和其他微生物向干预措施的证据.
主要成果:
- 大多数研究都是小的和横截面的,但一些细菌种群 (例如,Eubacterium,Coprococcus,Faecalibacterium) 可能在GAD中被耗尽.
- 对PD和SAD的研究是有限的;缺少 agoraphobia的研究.
- 益生菌可以提供适度的焦虑症状减轻,主要在非临床人群.
结论:
- 肠道微生物群-肠道-大脑轴是理解焦虑障碍的一个有希望的领域.
- 更大的前性研究是必要的,以证实发现和建立因果关系.
- 迫切需要针对临床焦虑群体的微生物组进行随机对照试验.
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