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美国成年人与胆结石有关的长期体重变化模式:来自NHANESES的证据
Peng Chen1, Mingxin Bai2, Yunbing Wang3
1Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
BMC gastroenterology
|April 12, 2025
概括
从成年早期保持肥胖会显著增加胆结石的风险. 预防或管理早期成人肥胖可能有助于预防胆结石.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 代谢健康 代谢健康
背景情况:
- 胆结石在美国是一个重大的健康问题.
- 了解体重变化对胆结石发展的长期影响对于公共卫生至关重要.
- 以前的研究还没有完全阐明特定体重变化模式与胆结石形成之间的关联.
研究的目的:
- 为了研究整个成年期体重变化模式与胆结石患病率之间的联系.
- 为了确定可能影响胆结石风险的体重变化的关键时期.
- 通过体重管理策略,为胆结石的初级预防提供证据.
主要方法:
- 分析了2017-2020年国家健康和营养检查调查 (NHANES) 的数据.
- 包括40至70岁的参与者,在三个不同的时间点分类身体质量指数 (BMI).
- 利用加权后勤回归来评估体重状况,体重变化模式和胆结石发生之间的关系.
主要成果:
- 25岁的肥胖与胆结石风险增加86% (OR1.86) 有关.
- 从25岁到基线的稳定肥胖模式显示出与胆结石有显著的积极关联 (OR 1.94).
- 在女性,糖尿病患者和身体活动较低的人群中观察到更强烈的关联.
结论:
- 从成年早期持续的肥胖是胆结石的重要危险因素.
- 旨在预防或控制成年早期肥胖的干预措施可以有效地预防胆结石的初级预防.
- 公共卫生战略应强调从年轻成人开始的长期体重管理.
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