基库奇 - 藤本病与儿童无菌性脑膜炎或脑炎并发:一个病例控制研究
1Department of Infectious Diseases, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, National Center for Children's Infectious and Allergic Diseases Surveillance, Beijing Research Center for Respiratory Infectious Diseases, Beijing Key Laboratory of Core Technologies for the Prevention and Treatment of Emerging Infectious Diseases in Children, Key Laboratory of Major Diseases in Children, Ministry of Education, No. 56 Nan Lishi Road, Beijing, 100045, China.
儿童的基库奇 - 藤本病可能涉及中枢神经系统,出现发烧和头痛等症状. 在患有无菌性脑膜炎或脑炎的儿童中,特别是淋巴结胀的儿童中,考虑基库奇-藤本病.
科学领域:
- 儿科神经学 儿科神经学
- 传染性疾病 传染性疾病
- 类风湿病学 类风湿病学
背景情况:
- 基库奇-富士本病 (KFD) 是一种罕见的,自我限制的疾病.
- 中枢神经系统 (CNS) 参与儿科KFD并不常见,但严重.
- 这项研究侧重于KFD与儿童无菌性脑膜炎或脑炎并发.
研究的目的:
- 总结儿科KFD中枢神经系统参与的临床和实验室特征.
- 在KFD患者中识别与无菌性脑膜炎或脑炎相关的特征.
- 帮助对儿童中枢神经系统感染的差异诊断.
主要方法:
- 进行了一项病例控制研究.
- 分析了64例儿科KFD病例的数据 (16例中枢神经系统参与,48例对照).
- 临床和实验室检测结果在各组之间进行了比较.
主要成果:
- 涉及中枢神经系统的16例病例的中位年龄为8岁,发烧和宫淋巴结敏感性是常见的.
- 在头部成像上,在11例病例中观察到白血脑病变.
- 宫淋巴结的疼痛,头痛,困惑,,高C反应蛋白和高乳酸脱酶与中枢神经系统的参与有显著的关联.
结论:
- 患有宫淋巴结敏感,C-反应蛋白升高或乳酸脱酶升高的儿科KFD患者需要评估中枢神经系统的参与.
- 对于患有无菌性脑膜炎或脑炎的儿童,在差异诊断中应考虑基库奇-藤本病.
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