大脑衍生的神经营养因子异型的动脉静脉差异在不同强度的运动后在大脑和肌肉中形成
Olga Tarassova1,2, Yiwen Jiang1, Helena Wallin3,4
1Department of Physical Activity and Health, The Swedish School of Sport and Health Sciences (GIH), Stockholm, Sweden.
The Journal of physiology
|April 13, 2025
概括
运动会增加循环的大脑衍生神经营养因子 (BDNF) 水平,但血清成熟的BDNF (mBDNF) 的增加来自血小板,而不是大脑或肌肉. 骨肌肉在高强度运动期间释放proBDNF.
科学领域:
- 运动生理学 运动生理学
- 神经科学是一个神经科学.
- 生物化学 生物化学
背景情况:
- 大脑衍生神经营养因子 (BDNF) 对神经可塑性至关重要.
- 众所周知,运动会增加循环中的BDNF水平,通常被认为是来自大脑的.
- 运动诱导的BDNF变化的确切来源尚不清楚.
研究的目的:
- 研究运动强度对循环成熟BDNF (mBDNF) 和proBDNF的影响.
- 确定大脑和骨肌肉对运动诱导的BDNF变化的贡献.
- 为了澄清运动后血清mbbDNF增加的来源.
主要方法:
- 健康的成年人 (n=16) 以40%,60%和80%的强度进行20分钟的骑自行车.
- 血液样本从手臂动脉, jugular 静脉,大腿静脉和前静脉收集.
- 大脑和骨肌肉的BDNF交换是使用动脉静脉差异和血流来计算的.
主要成果:
- 运动以强度依赖的方式增加了血小板计数,血清mBDNF和血proBDNF.
- 没有发现mBDNF或proBDNF的显著大脑交换 (释放或吸收).
- 高强度运动导致肌肉吸收血mBDNF和释放血proBDNF.
结论:
- 运动诱导的血清mbbDNF增加主要归因于血小板数量的增加,而不是大脑或肌肉释放.
- 大脑不会在运动后释放BDNF进入循环,无论运动的强度如何.
- 训练的骨肌肉释放proBDNF,特别是在更高的强度下.
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