在老鼠,和人类大脑网络中丰富俱乐部属性的演变:功能整合,分离和平衡的研究
Xiaoru Zhang1,2, Ming Song3,4,5, Wentao Jiang1,6
1Brainnetome Center, Laboratory of Brain Atlas and Brain-inspired Intelligence, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
Neuroscience bulletin
|April 13, 2025
概括
大脑的丰富俱乐部,一个高度连接的区域网络,增强整个大脑的功能整合跨物种. 高级物种表现出更大的融合,为大脑结构和功能提供了进化洞察力.
科学领域:
- 神经科学是一个神经科学.
- 网络科学 网络科学
- 比较生物学的比较生物学
背景情况:
- 富人俱乐部是一个由高度相互连接的节点组成的核心网络,是网络拓学的核心.
- 了解丰富俱乐部在大脑功能整合和跨物种隔离中的作用至关重要,但在很大程度上是未知的.
研究的目的:
- 检测和验证老鼠,子和人类结构性大脑网络中的丰富俱乐部.
- 评估丰富俱乐部对这些物种的功能融合,隔离和平衡的贡献.
主要方法:
- 在结构网络中使用神经元追踪和扩散MRI进行丰富的俱乐部检测和验证.
- 功能整合,分离和平衡指标的定量评估.
主要成果:
- 一个丰富的俱乐部在所有三种物种的结构性大脑网络中被确定和验证.
- 丰富的俱乐部的存在有助于跨物种的全脑功能整合.
- 高等物种 (子,人类) 的功能网络与低等物种 (老鼠) 相比,表现出更大的整合性.
结论:
- 大脑的丰富俱乐部是一个保存的特征,支持哺乳动物进化中的功能整合.
- 丰富的俱乐部组织中的特定物种差异可能是功能整合的基础.
- 这些发现提升了对大脑进化背景下的结构功能关系的理解.
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