运动神经元疾病中认知障碍的患病率:替代规范方法导致相当不同的估计
Francesca Oliveri1, Manuel Bicaj2, Marta Cillerai1
1Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.
Amyotrophic lateral sclerosis & frontotemporal degeneration
|April 13, 2025
概括
规范化方法对运动神经元疾病 (MND) 的认知障碍检测有显著影响. 基于回归 (R) 的方法与基于2个标准偏差 (2SD) 的方法相比,产生了较低的认知障碍 (CI) 患病率估计.
科学领域:
- 神经学 神经学
- 神经心理学 神经心理学
- 临床评估 临床评估
背景情况:
- 认知障碍 (CI) 在运动神经元疾病 (MND) 中很常见.
- 爱丁堡认知和行为ALS屏幕 (ECAS) 被广泛用于评估MND的CI.
- 意大利ECAS有两种规范方法:基于回归 (R) 和基于标准偏差 (2SD) 的两种规范方法.
研究的目的:
- 为了比较R和2SD规范方法来检测MND患者的CI.
- 评估不同规范方法对IC患病率估计的影响.
主要方法:
- 分析了160名MND患者的原始ECAS分数.
- 使用R和2SD规范方法纠正得分.
- 用Strong的标准对患者进行分类:认知正常 (CN),CI (ALSci),行为障碍 (ALSbi) 或两者 (ALScbi).
主要成果:
- 2SD方法显示,与R方法 (总共3.12%) 相比,低于截止值得分的患病率显著更高 (共25.62%).
- 在大多数ECAS分数中观察到这种差异,除了数字跨度向后.
- 与R方法 (7.50%) 相比,2SD方法导致ALSci的诊断率更高 (24.38%).
结论:
- 规范化方法对MND中CI的估计患病率产生了重大影响.
- R方法提供了更保守的CI患病率估计.
- 协调协议对于在未来的MND研究中进行一致的CI评估至关重要.
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