在初发躁狂的青少年中,长度大脑年龄被用或奎蒂阿平治疗
Laura K M Han1, Niousha Dehestani2, Chao Suo3
1Department of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia; Orygen, Parkville, VIC, Australia.
概括
患有第一发狂躁症 (FEM) 的年轻人表现出看起来更老的大脑,但和奎胺治疗没有改变超过12个月的大脑年龄. 需要进一步的研究来证实这些药物的长期神经保护作用.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 放射学 放射学是一门学科.
背景情况:
- 在早期双相情感和精神分裂症中,和奎平的神经保护作用尚不清楚.
- 在这些疾病的早期阶段,大脑的结构变化尚未得到充分理解.
研究的目的:
- 通过使用大脑年龄预测来研究和氨酸的神经保护作用.
- 通过使用脑-PAD.使用第一次发作躁狂 (FEM) 检查大脑结构差异.
- 评估基线脑PAD与治疗结果之间的关系.
主要方法:
- 利用在超过53,000次脑扫描中训练的深度学习模型来预测大脑年龄.
- 在39名FEM参与者和29名对照人群中评估了大脑PAD (预测大脑年龄 - 时间年龄).
- 收集了T1加权的MRI扫描在基线,3个月和12个月的FEM参与者在或氨酸单疗法.
主要成果:
- 与对照人群相比,患有FEM的年轻人表现出更高的基线脑PAD (看起来老的大脑) (+1.70年,p=0.04).
- 在12个月的时间里,在治疗组和治疗组中没有观察到脑PAD的显著变化.
- 基线脑PAD没有预测12个月后的症状,生活质量或功能结果.
结论:
- 虽然年轻的FEM患者的大脑看起来已经老了,但大脑-PAD无论或氨酸治疗如何,都保持稳定.
- 目前的研究结果不支持或氨酸对双相情感和精神分裂情感障碍早期大脑年龄的神经保护作用.
- 需要更长的随访时间和更大的样本大小来确定潜在的延迟治疗效应.
相关概念视频
Longitudinal Research
11.8K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
11.8K
Longitudinal Studies
91
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
91
Bipolar Disorder
37
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
37
Long-term Depression
2.4K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
2.4K


