探讨多管道益生菌补充剂对健康老年人认知功能和情绪的急性和慢性影响:一项随机对照试验
Jessica Eastwood1, Saskia van Hemert2, Maria Stolaki2
1School of Psychology and Clinical Language Sciences, University of Reading, Reading, United Kingdom.
The American journal of clinical nutrition
|April 13, 2025
概括
益生菌补充剂可以提高认知功能,降低健康老年人的抑郁风险. 急性摄入改善了执行功能反应时间,而长期使用减少了负面的认知偏见和反.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 老年学是指老年学的学科.
背景情况:
- 衰老与认知能力下降和抑郁症风险增加有关.
- 益生菌在临床小组中对认知和情绪有希望.
- 对于与年龄相关的认知能力下降的健康老年人的好处尚不清楚.
研究的目的:
- 研究多种益生菌对健康老年成年人认知的慢性影响.
- 探索益生菌对情绪,肠道微生物群和急性认知/情绪反应的影响.
主要方法:
- 一个随机的,安慰剂控制的交叉试验,涉及30名健康的老年人.
- 评估了急性 (1天) 和慢性 (8周) 益生菌对执行功能,记忆和情绪的影响.
- 在干预前和后使用16s rRNA测序分析了肠道微生物群.
主要成果:
- 急性益生菌使用缩短了要求执行功能任务的反应时间.
- 慢性补充改善了与抑郁症脆弱性 (绝望,反,侵略) 相关的认知偏见.
- 在高认知负载下观察到执行功能的潜在改善.
结论:
- 益生菌对执行功能反应时间产生了急性影响.
- 慢性益生菌摄入可以通过改善对悲伤情绪的认知反应来降低健康老年人的抑郁风险.
- 这些发现值得复制,并进一步研究益生菌机制.
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