在不同的临床环境中,suPAR作为支持的生物标志物
Fabio Belvederi1, Simone Leggeri1, Andrea Urbani2
1Department of Basic Biotechnological Sciences, Intensive Care and Perioperative Clinics, Catholic University of Sacred Heart, 00168 Rome, Italy.
概括
溶解性尿基酶类型等离子体激活受体 (suPAR) 是炎症和疾病严重程度的生物标志物. 诊断测试的进步改善了它在各种疾病的临床应用.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 泌尿酸酶类型的等离子体激活体受体 (uPAR) 系统对于细胞功能至关重要,包括免疫激活,迁移和组织重塑.
- 循环中的可溶性UPAR (suPAR) 作为系统性炎症和免疫反应的生物标志物.
- 升高的suPAR水平与感染,败血症,心血管疾病,损伤,癌症和自身免疫疾病的疾病严重程度相关,具有预后价值,特别是在急性情况下.
研究的目的:
- 审查suPAR生物标志物,涵盖其生物化学结构,生物功能和测量方法.
- 探索suPAR在不同医学领域的临床相关性和应用.
- 为了突出suPAR诊断技术的最新进展.
主要方法:
- 关于UPAR系统和suPAR生物标记物的现有文献的审查.
- 讨论suPAR的生化特性和生物作用.
- 对suPAR量化现有和新兴诊断方法的分析.
主要成果:
- suPAR是系统性炎症和免疫激活的验证生物标志物.
- suPAR水平与各种疾病的严重程度和预后有关.
- 最近的诊断进步,包括快速测试和度测试,提高了suPAR的临床实用性.
结论:
- suPAR是一种重要的生物标志物,具有广泛的临床应用,特别是在评估炎症和疾病预后方面.
- 改善了suPAR测量的诊断准确性和可访问性,使其更容易被纳入临床实践.
- 对suPAR在各种疾病中的作用的进一步研究有望扩大其治疗和诊断潜力.
相关概念视频
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
38
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
38
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
69
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
69