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Updated: Jun 28, 2026

Quantitative Multispectral Analysis Following Fluorescent Tissue Transplant for Visualization of Cell Origins, Types, and Interactions
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Quantitative Multispectral Analysis Following Fluorescent Tissue Transplant for Visualization of Cell Origins, Types, and Interactions

Published on: September 22, 2013

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基因特征在血素和色染色图像中的空间映射:使用附加多实例学习进行可解释预测的概念验证

Miles Markey1, Juhyun Kim1, Zvi Goldstein1

  • 1PathAI, Boston, Massachusetts.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
|April 13, 2025
PubMed
概括

机器学习可以从组织学图像中预测癌症相关纤维细胞 (CAF) 亚型. 这种方法将组织特征与基因表达联系起来,为癌症免疫治疗提供可解释的生物标志物.

关键词:
生物标志物 生物标志物计算病理学计算病理学基因表达签名 基因表达签名机器学习是机器学习.

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Multiplexed Barcoding Image Analysis for Immunoprofiling and Spatial Mapping Characterization in the Single-Cell Analysis of Paraffin Tissue Samples08:18

Multiplexed Barcoding Image Analysis for Immunoprofiling and Spatial Mapping Characterization in the Single-Cell Analysis of Paraffin Tissue Samples

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相关概念视频

Genetic Lingo01:11

Genetic Lingo

Overview
Pedigree Analysis01:35

Pedigree Analysis

Overview
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
Epistasis01:39

Epistasis

In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
Gene Duplication and Divergence02:37

Gene Duplication and Divergence

The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was  generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are characterized.