儿科瘤学患者的药物基因组学与化学疗法诱导的毒性相关的固体瘤:系统性审查
Paula Hansson1, Christopher Blacker1, Hanna Uvdal2
1Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Critical reviews in oncology/hematology
|April 13, 2025
概括
药物基因组学表明,有望减少固体瘤儿童的化疗副作用. 然而,与骨髓抑制和心脏毒性等毒性的遗传联系是复杂的,需要进行更多的临床研究.
科学领域:
- 儿科瘤学 儿科瘤学
- 药物基因组学 药物基因组学
- 毒理学 毒理学 毒理学
背景情况:
- 化疗引起的毒性显著影响儿科癌症患者的治疗结果和生活质量.
- 遗传变异导致化学疗法毒性的个体差异.
- 药物基因组学提供了个性化治疗和减轻不良事件的潜在策略.
研究的目的:
- 审查现有的关于儿科固体瘤化疗诱导毒性的药物基因组学研究.
- 识别与常见毒性相关的特定遗传变异.
- 突出这一领域的挑战和未来方向.
主要方法:
- 在PubMed,Embase和Web of Science中进行系统的文献搜索,遵循PRISMA指南.
- 独立审查文章的资格和偏见风险 (ROBINS-I).
- 从相关研究中提取数据并综合相关研究的发现.
主要成果:
- 包括24项具有偏差风险低至中等的研究,重点是患有固体瘤的儿童.
- 对于甲状腺素毒性 (ABCC2,MTHFR,SXR) 和基于的药物耳毒性 (ABCC3,COMT,ERCC2,GSTP1,GSTT1,LRP2,SLC22A2,TPMT) 发现的关联.
- 与包括CBR2,CELF4,GSTM1,RARG,SLC28A3在内的基因相关的心脏毒性,在年幼的儿童,女性和男性中具有特定的关联.
结论:
- 在儿科瘤学中,与化疗毒性的药物基因组学关联是复杂和可变的.
- 某些遗传变异显示出与特定毒性的潜在联系,但需要进一步验证.
- 更大规模的跨国研究对于加强证据和为个性化儿科癌症治疗提供临床指南至关重要.
更多相关视频
09:19Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
Published on: February 6, 2015
8.7K
08:59Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
Published on: December 11, 2017
7.2K
相关概念视频
Nonlinear Pharmacokinetics: Overview
311
Nonlinear or dose-dependent pharmacokinetics is a phenomenon that occurs when the pharmacokinetic parameters of certain drugs deviate from linear pharmacokinetics at higher doses. These drugs do not follow the expected first-order kinetics, where the rate of drug elimination is directly proportional to the drug concentration. Instead, they exhibit a nonlinear relationship, which can be attributed to several factors.
Nonlinearity can arise due to the saturation of plasma protein-binding or...
Nonlinearity can arise due to the saturation of plasma protein-binding or...
311
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Analysis of Population Pharmacokinetic Data
240
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
240
Factors Affecting Drug Response: Overview
1.9K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
1.9K
Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
Nonlinear Pharmacokinetics: Role of Transporters
41
A drug's nonlinear kinetics can be influenced by a diverse range of transporter proteins that serve as crucial players in drug distribution. These transporters, found within cells, can enhance or reduce local drug concentrations by facilitating the influx or efflux of drugs. For instance, the expression of xenobiotic transporters can be influenced by factors such as age and gender, potentially impacting the linearity of drug response.
Polymorphisms occurring in drug transporters can alter...
Polymorphisms occurring in drug transporters can alter...
41
