EAT-Lancet行星健康饮食和发病痴呆症之间的关联
Jessica Samuelsson1, Isabelle Glans2, Anna Stubbendorff3
1Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health at the University of Gothenburg, Wallinsgatan 6, Mölndal 43139, Sweden; Nutritional Epidemiology, Department of Clinical Sciences Malmö, Lund University, Jan Waldenströms gata 35, Malmö 21428, Sweden.
The journal of prevention of Alzheimer's disease
|April 13, 2025
概括
坚持EAT-Lancet饮食可能会降低痴呆风险,特别是那些没有APOE ε4基因变异的人. 这种植物向前的饮食模式对痴呆风险没有不利影响.
科学领域:
- 营养流行病学 营养流行病学
- 神经退行性疾病研究研究
- 公共卫生 营养 公共卫生 营养
背景情况:
- 促进环境可持续性和健康的EAT-Lancet饮食对痴呆风险的影响尚不清楚.
- 了解饮食对认知衰退的影响对于预防策略至关重要.
研究的目的:
- 调查遵守EAT-Lancet饮食与所有原因痴呆症,阿尔茨海默病 (AD) 和血管痴呆症 (VaD) 的发生率之间的关联.
- 探索APOE ε4基因型在饮食-痴呆症关系中的潜在修饰作用.
主要方法:
- 来自马尔默饮食和癌症研究的25898名参与者 (年龄在45-73岁之间) 的队列被跟踪了平均18年.
- 七个EAT-Lancet饮食得分被用于评估坚持,并应用了多次调整的Cox比例危险模型.
- 该研究检查了与所有原因痴呆症,AD和VaD的关联,并分析了与APOE ε4状态的相互作用.
主要成果:
- 在一些分析中,对EAT-Lancet饮食的更高坚持与阿尔茨海默病和全因痴呆症风险降低有关.
- 在APOE ε4非载体中观察到对AD和全因痴呆症的显著降低风险效应,但在载体中没有.
- 与EAT-Lancet饮食有关的血管痴呆症 (VaD) 没有发现显著的关联.
结论:
- 坚持EAT-Lancet饮食可能会对痴呆症产生保护作用,特别是对于那些不是APOE ε4携带者的人.
- 这些发现强调了在预防痴呆症的饮食干预中考虑APOE ε4状态等遗传因素的重要性.
- 评估EAT-Lancet饮食的方法变化需要在未来的研究中进一步调查.
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