极低出生体重婴儿生存率中的性别差异:来自16年单中心研究的见解
1Department of Paediatrics, Ministry of National Guard Health Affairs (MNGHA), King Abdulaziz Medical City, Jeddah, Kingdom of Saudi Arabia.
Journal of neonatal-perinatal medicine
|April 13, 2025
概括
女性极低出生体重 (ELBW) 婴儿的存活率高于男性. 这种生存优势在体重小于750克的婴儿中尤为明显.
科学领域:
- 新生儿科学 新生儿科学
- 周围生理学 周围生理学
- 儿科生存研究的研究.
背景情况:
- 极低出生体重 (ELBW) 婴儿 (<1000g) 是一个具有显著新生儿死亡率和发病率的脆弱人群.
- 尽管他们的活产比例很低,但ELBW婴儿对新生儿死亡和长期健康问题做出了不成比例的贡献.
- 了解ELBW婴儿的生存趋势和影响因素对于改善新生儿护理至关重要.
研究的目的:
- 在16年的时间内分析极低出生体重 (ELBW) 婴儿的生存趋势.
- 调查婴儿性别对ELBW婴儿的生存几率的影响.
- 确定特定的出生体重值,在这些值中性别差异最为显著.
主要方法:
- 从2008年到2023年,对入住新生儿重症监护病房的ELBW婴儿进行了回顾性队列研究.
- 根据婴儿性别分层的生存率的分析.
- 统计评估生存几率,包括几率比率和p值,以确定显著性.
主要成果:
- 总共有336名ELBW婴儿被纳入:有175名男性 (52.1%) 和161名女性 (47.9%).
- 与男性 (68.6%) 相比,女性ELBW婴儿的生存率 (78.9%) 较高,几率比率为1.712 (p=0.017).
- 女性的生存优势在出生体重低于750克的婴儿中更为明显 (62%对44%),赔率比为2.06 (p=0.023).
结论:
- 与男性同行相比,女性ELBW婴儿的存活率在统计学上显著地更高.
- 女 ELBW 婴儿的生存益处在极低出生体重 (<750g) 类别中尤为明显.
- 这些发现强调了在ELBW婴儿的管理和预后中考虑性别的重要性.
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