血CCL3预测了心律失常性心肌病症患者的不良心力衰竭结果
Hao Cui1,2, Songren Shu1,3, Ningning Zhang1
1The Cardiomyopathy Research Group, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167A Beilishi Road, Xi Cheng District, Beijing, 100037, China.
在心律失常性心肌病 (ACM) 中的纤维脂肪组织显示和甘油三和炎症标记物增加,与心力衰竭 (HF) 的进展相关. 血CCL3水平预测ACM患者的不良事件,有助于风险分层.
科学领域:
- 心脏病学 心脏病学
- 病理学 病理学 病理学
- 生物化学 生化学
背景情况:
- 节律失调性心肌病 (ACM) 涉及纤维脂肪心肌置换,与心力衰竭 (HF) 的进展有关.
- 在ACM患者中研究纤维脂肪组织和血化学水平的特征对于了解高压负担至关重要.
研究的目的:
- 在ACM患者中描述纤维脂肪组织,重点关注脂肪标记物,脂组学和免疫细胞透.
- 为了评估纤维脂肪组织组成,血化学激素水平 (CCL3) 和ACM中HF进展之间的相关性.
- 评估血CCL3对ACM中心血管不良事件的预测值.
主要方法:
- 脂肪标记物的定量实时PCR (棕色,色,白色).
- 脂管学 (LC-MS) 和心肌组织单细胞RNA测序.
- 免疫染和ELISA用于组织和血中的CCL3表达.
- 对ACM患者进行长度随访,以评估HF发病率和结果.
主要成果:
- 与对照人群相比,ACM纤维脂肪组织表现出更高的色和棕色脂肪标记物表达和和甘油三酸的增加.
- 在ACM心肌中,出现了益炎性巨细胞的积累和高的益炎性标志物.
- 纤维脂肪组织中的CCL3表达与HF进展具有积极的相关性.
- 血CCL3水平在ACM患者中升高,并预测HF发病率和心脏移植/死亡 (HF的AUC为0.814,HTx的0.756/死亡).
结论:
- 在ACM纤维脂肪组织中和甘油三和CCL3的增加可能会推动HF的进展.
- 血CCL3作为一个有价值的生物标志物,用于预测ACM患者的HF相关不良事件.
- 需要在更大的队列中进一步验证,以确认血CCL3.3的预测效用.
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