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Updated: Jun 26, 2026

An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses
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一个体内"转向模型"揭示了RanBP9在肺巨细胞中的新相互作用

Yasuko Kajimura1,2, Shuxin Dong3, Anna Tessari1,4

  • 1Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University Arthur G. James Comprehensive Cancer Center, Columbus, OH, 43210, USA.

Cell death discovery
|April 13, 2025
PubMed
概括

支架蛋白 Ran 结合蛋白 9 (RanBP9) 在巨细胞中具有未知的功能. 一个新的小鼠模型显示,RanBP9与不同的蛋白质集相互作用,影响免疫反应和新陈代谢.

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相关概念视频

Directionality of Nuclear Transport01:42

Directionality of Nuclear Transport

Ras-related nuclear protein or Ran is a small G protein that cycles between its GTP and GDP bound states. Ran specific regulators, a Ran GTPase Activating Protein or RanGAP present in the cytosol and a Ran guanine nucleotide exchange factor or RanGEF present inside the nucleus regulate GTP/GDP exchange. A high concentration of GTP inside the cells, in addition to this asymmetric distribution of  Ran-specific regulators, leads to a higher RanGTP concentration inside the nucleus. This...