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Updated: May 13, 2025

Neuropharmacological Manipulation of Restrained and Free-flying Honey Bees, Apis mellifera
11:08

Neuropharmacological Manipulation of Restrained and Free-flying Honey Bees, Apis mellifera

Published on: November 26, 2016

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基于蜜蜂GABA受体的低蜜蜂毒性异佐林衍生物的合理设计和合成

Jianrong Yang1, Hong Tu1, Bihong Tian1

  • 1State Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Huaxi District, Guiyang 550025, China.

Journal of agricultural and food chemistry
|April 14, 2025
PubMed
概括

研究人员修改了杀虫剂fluralaner,以减少蜜蜂的毒性,同时保持杀虫活性. 化合物A13是一个更安全的替代品,对蜜蜂的毒性明显降低,对钻石背和秋季军虫有有效的害虫防治.

关键词:
对于蜜蜂的毒性这种杀虫剂是isoxazoline.分子动力学分子动力学硫二胺的 thiophene 的含量

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Anti-RDL and Anti-mGlutR1 Receptors Antibody Testing in Honeybee Brain Sections using CRISPR-Cas909:25

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Direct alkylation is not a suitable method for synthesizing amines because it produces polyalkylated products. Gabriel synthesis is the most preferred method to exclusively make primary amines. The method uses phthalimide, which contains a protected form of nitrogen that participates in alkylation only once to predominantly give primary amines.
Strong bases like NaOH or KOH deprotonate the phthalimide to form the corresponding anion, which acts as a nucleophile. Further, the anion attacks an...
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Direct alkylation of ammonia produces polyalkylated amines, along with a quaternary ammonium salt. To exclusively prepare primary amines, the azide synthesis method can be used.
Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
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