血代谢的变化与母亲在第一个三个月和胎儿生长期间吸烟有关
Wadzanai Masvosva1, Taija Voutilainen1, Marko Lehtonen1
1School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
Basic & clinical pharmacology & toxicology
|April 14, 2025
概括
怀孕早期母亲吸烟会改变与内分泌干扰和氧化应激相关的代谢物. 这些变化与胎儿生长问题相关,例如出生时体重低和头周长较小.
科学领域:
- 代谢学 代谢学 代谢学
- 生殖健康 生殖健康
- 环境健康 环境健康
背景情况:
- 母亲吸烟是妊娠不良结果的已知危险因素,包括低出生体重.
- 第一季度吸烟引起的特定代谢变化及其对胎儿发育的影响需要进一步阐明.
研究的目的:
- 为了识别与第一季度吸烟相关的母亲代谢的变化.
- 为了将这些代谢变化与胎儿生长参数相关联.
主要方法:
- 利用非向的液态染色体质谱测量,对227名孕妇的血中代谢物进行分析.
- 通过自我报告和血中胆固醇水平来验证吸烟状态.
- 分析了吸烟者与非吸烟者之间64种重要的代谢物差异.
主要成果:
- 鉴定了与内分泌干扰相关的代谢物 (例如,脱氨二硫酸[DHEA-S]),氧化应激 (例如, bilirubin) 和脂质代谢 (例如,LysoPC 16:1) 的显著差异.
- DHEA-S和胆红素水平与低出生体重相关.
- LysoPC 16:1水平与出生时头部周长较小相关.
结论:
- 怀孕第一季度母亲吸烟与明显改变的代谢物概况有关.
- 这些代谢变化与内分泌干扰和氧化应激增加有关.
- 已识别的代谢物为吸烟引起的胎儿生长限制提供了潜在的生物标志物.
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